TABLE 4.
Mean baseline renal function parameters by treatment group
| Dosage group (n) | Arithmetic mean (SD) result for parameter:
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| SC (mg/dl) | GFR (ml/min/1.73 m2) | ERPF (ml/min/1.73 m2) | FF (%) | CrCL (ml/min/1.73 m2) | EGCE (ml/min/1.73 m2) | BUN (mg/dl) | Serum UA (mg/dl) | UC (mg/dl) | |
| Placeboa (15-16) | 0.98 (0.13) | 95.86 (8.81) | 521.60 (166.38) | 0.21 (0.05) | 109.58 (13.49) | 16.02 (12.83) | 12.66 (2.64) | 4.71 (1.29) | 86.48 (32.60) |
| 800 mga (20-21) | 0.95 (0.13) | 98.46 (9.56) | 515.44 (183.67) | 0.93 (2.05) | 106.42 (13.58) | 7.18 (9.85) | 11.35 (2.44) | 4.53 (1.10) | 85.06 (23.79) |
| 1,000 mg (10) | 0.91 (0.10) | 93.62 (12.22) | 486.24 (106.87) | 0.23 (0.06) | 107.82 (12.60) | 17.92 (13.12) | 11.88 (1.27) | 3.97 (0.86) | 80.00 (27.76) |
a
Data were not available for all subjects for some parameters in this dose group.