TABLE 5.
Mean day 8 renal function parameter change-from-baseline values by treatment group
| Dosage group (n) | Day 8 change-from-baseline arithmetic mean (SD) result for parameter:
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| SC (mg/dl) | GFR (ml/min/1.73 m2) | ERPF (ml/min/1.73 m2) | FF (%) | CrCL (ml/min/1.73 m2) | EGCE (ml/min/1.73 m2) | BUN (mg/dl) | Serum UA (mg/dl) | UC (mg/dl) | |
| Placebo (15) | 0.02 (0.05) | −6.43 (6.69) | 102.38 (218.28) | −0.04 (0.05) | −13.17 (18.72) | −9.56 (19.90) | 1.10 (2.05) | 0.05 (0.40) | −28.50 (20.30) |
| PA-824a (800 mg) (20-21) | 0.18d (0.06) | −6.11 (6.36) | 130.27 (484.36) | −0.77 (2.10) | −21.78b (10.67) | −15.80c (13.06) | 1.53 (2.33) | −0.13 (0.45) | −15.15 (40.02) |
| PA-824 (1,000 mg) (10) | 0.25d (0.07) | −2.88 (10.16) | 2.80 (90.62) | −0.03 (0.06) | −21.60b (8.53) | −22.44b (13.88) | 0.73 (0.88) | −0.39b (0.50) | −17.70 (15.78) |
a
Data were not available for all subjects for some parameters in this dosage group.
b
P < 0.10.
c
P < 0.05.
d
P < 0.0001.