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Summary of echinocandin MIC (A) and IC50 (B) values for the C. glabrata strains harboring various Fks1p and Fks2p amino acid substitutions. Lines represent average MICs and IC50s for ANF, CSF, and MCF for the group of mutants harboring amino acid substitutions in each Fks protein. MICs were obtained using the CLSI document M27-A3 guidelines, and IC50s were obtained using product entrapped partially purified 1,3-β-d-glucan synthase enzyme complexes. WT, wild type.
