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MIC/IC50 correlation as a function of Fksp amino acid substitutions. The echinocandin drug ANF (A), CSF (B), or MCF (C) was used to obtain IC50 values and MICs in the presence of RPMI 1640 medium (CLSI document M27-A3) (4) or RPMI 1640 medium with 50% serum. Vertical dashed lines represent the CLSI susceptibility breakpoint (2 μg/ml). WT, wild type.
