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Ability of a prolonged infusion of 40 mg/kg to attain a trough free-drug concentration >1.7 times the baseline MIC, a value associated with resistance emergence suppression when meropenem is administered with an aminoglycoside, or to attain a trough free-drug concentration >6.2 times the baseline MIC, a value associated with resistance emergence suppression when meropenem is administered alone (33).
