TABLE 1.

Summary of pharmacokinetic blood sampling

Study day	Sampling time(s) for the following L-AMB dosing groups:
	1 mg/kg/day	7.5 mg/kg/wk	15 mg/kg, single dose
1	Predosing, end of infusion (2 h), 4 h, and 8 h	Predosing, end of infusion (2 h), 4 h, and 8 h	Predosing, end of infusion (2 h), 4 h, and 8 h
2	Prior to dosing (24 h)	24 h postdosing	24 h postdosing
3-6	Prior to dosing on days 4 and 6	Single samples at 72 and 120 h postdosing	Single samples at 72 and 120 h postdosing
7	Predosing, end of infusion (2 h), 4 h, and 8 h	Predosing, end of infusion (2 h), 4 h, and 8 h	Single sample 144 h postdosing
8	Prior to dosing (24 h)	24 h postdosing	Single sample 168 h postdosing
9-15	Single samples prior to dosing on days 10, 12, 14, and 15	Single samples at 72, 120, 168, and 192 h postinfusion	No samples collected
16	24 h after day 15 dose	No samples collected	No samples collected