TABLE 4.
Buccal mucosal tissue and plasma AMB Cmin data
| Dosing group | Day 7
|
Day 15
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Plasma AMB
|
Buccal mucosal tissue AMB
|
Tissue concn/plasma concn ratio
|
Plasma AMB
|
Buccal mucosal tissue AMB
|
Tissue concn/plasma concn ratio
|
|||||||
| Cmin (μg/ml)a | No. of patients | Cmin (μg/g)a | No. of patients | Ratioa | No. of patients | Cmin (μg/ml)a | No. of patients | Cmin (μg/g)a | No. of patients | Ratioa | No. of patients | |
| 1 mg/kg/day | 4.3 (6.5) | 6 | 9.7 (9.2) | 5 | 6.2 (8.6) | 5 | 1.8 (1.2) | 6 | 16.6 (13.7) | 6 | 10.6 (6.3) | 6 |
| 7.5 mg/kg x 2 | 0.318 (0.09) | 4 | 16.8 (18.2) | 4 | 47.2 (48.5) | 4 | 0.221 (0.09) | 3 | 4.4 (3.2) | 3 | 22.8 (18.6) | 3 |
| 15 mg/kg, single dose x 1 | 0.491 (0.19) | 5 | 8.1 (3.3) | 4 | 16.3 (7.9) | 4 | 10.8 (8.0) | 4 | ||||
a
Values are means (standard deviations).