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Effective inhibition of influenza virus infection of primary human pneumocytes by DAS181. Cultures were incubated with medium (vehicle) (A and C) or 500 U/ml DAS181 (B and D) for 2 h, followed by infection with influenza virus A/HK/54/98 (H1N1) (A and B) or A/VN/3046/04 (H5N1) (C and D). After being washed, the cultures were incubated for 18 h at 37°C before fixation and staining with an antibody against influenza virus antigen. Brown staining represents sites of antibody binding.
