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Proposed mechanisms of the genetic inversion in NRS387. (A) Location of the inverted repeat sequences harboring IS1181 in the ancestral NRS387-like strain. (B) Alignment of the inverted repeat sequences followed by reciprocal recombination. This recombination event causes the region to “flip.” (C) The current orientation of the inverted region in NRS387. (D) Divergence of FPR3757 and NRS387 from a common ancestor strain. ACME, arginine catabolite mobile element.
