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Growth of the M. tuberculosis sigB mutant in various models of infection. The survival of the M. tuberculosis wild-type H37Rv strain (diamonds), the sigB mutant strain (squares), and the complemented strain (circles) was analyzed in THP-1 macrophage-like cells (A), intravenously inoculated BALB/c mice (B), and aerosol-infected guinea pigs (C).
