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. 2009 Jul 13;77(9):4150–4160. doi: 10.1128/IAI.00683-09

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Copyright © 2009, American Society for Microbiology

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FIG. 7. — Attenuated virulence of rvs161Δ and rvs167Δ mutants in a mouse model of hematogenously disseminated candidiasis. Survival curves of mice infected with rvs161Δ (A), rvs162Δ (B), or rvs167Δ (C) compared with that of the wild-type strain DIC185. Note the reduced virulence of the rvs161Δ and rvs167Δ strains (P = 0.0001). The difference between the rvs161Δ and rvs167Δ strains was not statistically different. Strains used were YLD14 (rvs161Δ), YLD22 (rvs162Δ), YLD16 (rvs167Δ), YLD11 (rvs161Δ/rvs161Δ/RVS161), YLD12 (rvs167Δ/rvs167Δ/RVS167), and wild-type DIC185.