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. 2009 Jun 22;77(9):3639–3650. doi: 10.1128/IAI.00225-09

FIG. 1.

FIG. 1.

Experimental inoculation of animals with C. rodentium causes severe disease in C3H and FVB mice but not in SWR, SJL, or C57BL/6 mice. (A) Mortality of infected C3H mice and FVB mice, but not infected SWR, SJL, and C57BL/6 mice, was observed after 7 dpi (P < 0.0001). (B) Significant body weight (BW) loss was observed for infected C3H mice and FVB mice by 9 dpi (P < 0.005). Data were normalized to body weights of uninfected mice of the corresponding strains and are presented as mean differences ± SEM. (C) Fecal bacterial counts were highest in C3H mice and lowest in FVB mice at 3 dpi. Levels of fecal bacterial shedding were comparable between the strains on days 9 and 12, except for SJL mice, which had a delayed clearance of infection (P < 0.0001). Data were log transformed and are presented as mean differences ± SEM. *, P < 0.05; ***, P < 0.001 (compared with three other inbred strains). #, P < 0.05 compared with one or two other inbred strains.