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. 2009 Jun 22;77(9):3639–3650. doi: 10.1128/IAI.00225-09

FIG. 6.

FIG. 6.

C. rodentium infection induces chloride diarrhea in susceptible mice. (A and B) Infection resulted in chloride retention in feces (A) and hypochloremia (B) in C3H and FVB mice at 9 and 12 dpi, respectively (P < 0.001). Resistant SWR and C57BL/6 mice did not demonstrate abnormal fecal or serum chloride concentrations. Data are presented as mean differences ± SEM. (C) C3H and FVB mice demonstrated significant water loss in stool, reaching more than a 20% loss of initial fecal water content as disease progressed. The diarrheal response of resistant strains was comparable and less dramatic (P < 0.005). Data were normalized to water content in uninfected mice of the corresponding strains and are presented as mean differences ± SEM. The dashed line indicates the 20% water loss threshold. *, P < 0.05; **, P < 0.01; ***, P < 0.001 (compared with three other inbred strains). #, P < 0.05 compared with one or two other inbred strains.