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De novo biosynthesis of NAD. (A) Schematic diagram of NAD biosynthesis from aspartate to NaMN (E. coli gene names). In some archaea and thermotoga, the first step is catalyzed by aspartate dehydrogenase rather than aspartate oxidase (67). (B) Schematic diagram of NAD biosynthesis from tryptophan to NaMN (S. cerevisiae gene names).
