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Nicotinamide metabolism throughout the tree of life. The tree of life calculated with universally conserved proteins (17) was annotated on the basis of possession of apparent pncA and nadV orthologs. For each fully sequenced genome, we scored the organism as carrying nadV (1), pncA (2), both genes (3), or neither gene (0). (Adapted from reference 17 with permission from AAAS.)
