TABLE 2.

Comparison of amino acid sequences of HA, NA, and M2 genes of representative viruses from eastern China

Virus	Genotype	Residue at RBSa position:				NA deletion (aa)	Connecting peptideb	M2 residue at amantadine resistance mutation position
		183	190	226	228			27	31
Qa/HK/G1/97		H	E	L	G	38-39	R-S-S-R	V	S
Dk/HK/Y439/97		H	E	Q	G		A-S-N-R	V	S
Ck/Kor/323/96		H	E	Q	G		A-S-Y-R	V	S
Ck/HK/G9/97		N	A	L	G		R-S-S-R	V	S
Ck/BJ/1/94	A	N	V	Q	G		R-S-S-R	V	S
Ck/SD/1/98	A	N	T	Q	G	62-64	R-S-S-R	V	S
Ck/AH/1/98	A	N	V	Q	G	62-64	R-S-S-R	V	S
Ck/JS/1/98	A	N	V	Q	G	62-64	R-S-S-R	V	S
Ck/SH/F/98	H	N	A	Q	G	62-64	R-S-S-R	V	N
Ck/SD/1/99	A	N	V	Q	G	62-64	R-S-S-R	V	S
Ck/JS/1/99	J	N	T	Q	G	62-64	K-S-S-R	V	S
Ck/SH/2/99	H	N	A	Q	G	62-64	R-S-S-R	V	S
Ck/SD/1/00	A	N	V	Q	G	62-64	R-S-S-R	V	N
Ck/SH/3/00	H	N	T	Q	G	62-64	R-S-S-R	V	S
Ck/SH/1/01	H	N	T	L	G	62-64	R-S-S-R	V	S
Ck/JS/2/01	H	N	T	Q	G	62-64	K-S-S-R	V	S
Ck/AH/2/02	H	N	V	Q	G	62-64	R-S-S-R	V	N
Ck/JS/1/02	H	N	A	Q	G	62-64	R-S-S-R	V	S
Dk/ZJ/1/02	H	N	A	L	G	62-64	R-S-S-R	V	S
DK/JS/1/02	H	N	A	Q	G	62-64	R-S-S-R	V	S
Ck/HN/1/02	H	N	V	Q	G	62-64	R-L-S-R	V	S
Ck/SH/1/02	H	N	A	L	G	62-64	R-S-S-R	V	S
Ck/SD/1/03	K	N	V	L	G	62-64	R-S-S-R	V	S
Ck/HN/1/03	H	S	V	Q	G	62-64	R-S-S-R	V	I
Ck/JS/1/04	H	N	A	Q	G	62-64	K-S-S-R	V	N
Ck/SD/1/04	H	N	T	Q	G	62-64	R-S-S-R	A	S
Dk/JS/9/04	H	N	A	Q	G	62-64	R-S-S-R	V	N
Ck/HN/1/04	H	N	A	L	G	62-64	R-L-S-R	V	I
Ck/HN/2/04	H	S	V	L	G	62-64	R-L-S-R	V	I
Dk/JS/3/05	L	N	V	Q	G	62-64	R-S-S-R	V	S
Ck/HN/1/05	H	N	A	L	G	62-64	R-L-S-R	A	S

^aRBS, receptor binding site.

^bConnecting peptide from positions −4 to −1 of HA1. Boldface indicates the mutation amino acid motif at the cleavage site.