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. 2009 Jun 10;83(17):8379–8395. doi: 10.1128/JVI.00891-09

FIG. 7.

FIG. 7.

Distinct epistatic interactions among NS2, E1, and NS3. Relative viral infectivities were measured in medium collected at 8, 24, 48, and 96 h posttransfection. Values represent average relative infectivity measurements from at least three independent transfections; error bars represent the standard deviation of the mean. (A) Class 1 mutants were suppressed by NS3 Q221L and inhibited by E1 A78T. (B) Class 2 mutants were suppressed by E1 A78T and inhibited by NS3 Q221L. (C) Class 3 mutants were affected by NS3 Q221L and E1 A78T equally. (D) Class 3 triple mutants containing both E1 A78T and NS3 Q221L.