FIG. 9.

Summary of NS2 suppressors. (A) NS2 TM domain target sites that were suppressed by NS3 Q221L (left) and E1 A78T (right). (B) NS2 cysteine protease domain target sites that were suppressed by NS3 Q221L (purple) and NS2 G154D (red). The location of NS2 G154 is shown in blue. NS2 chain A is white, chain B is yellow, and detergent molecules are black. (C) Ribbon model of NS3 (see Materials and Methods) showing the serine protease domain (SER PROT) in pink, the protease-helicase linker in yellow, and helicase domains (HEL1, HEL2, and HEL3) in white, cyan, and blue, respectively. The NS4A cofactor peptide is green, serine protease active site residues are red, ATPase active site residues are purple, nucleic acid is black, and NS3 Q221 is blue.