TABLE 1.
Viremia, rash, sequence of replicating MV, and cellular immunity in infected rhesus monkeys
| Monkey ID | Viremiaa | Rash | Sequencec | CMI at indicated no. of wk p.i.d
|
|
|---|---|---|---|---|---|
| 4 | 12 | ||||
| 279 | 0 | No | Not available | 33 | 26 |
| 449 | 5 | No | Unchanged | 23 | 36 |
| 472 | 1b | No | Unchanged | 25 | 30 |
| 991 | 10 | No | Unchanged | 0 | 0 |
a
Viremia levels are expressed as TCID50/106 PBMC, assayed at 7 days after the first MV inoculation.
b
MV cytopathic effect is documented, but the titer is too low to be measured.
c
Sequences covered nucleotides 1244 to 2664 of the vectored MV genome, including the complete HBsAg coding region (nucleotides 1790 to 2470).
d
Cell-mediated immunity (CMI) was assayed at 4 or 12 weeks postinfection (wk p.i.) by IFN-γ enzyme-linked immunospot assay; numbers of spot-forming cells are after subtraction of the paired medium control and adjusted to 106 PBMC.