FIG. 4.

Menin regulates transcription of PPARγ target genes. (A) The menin (no. 1), menin L22R (no. 2), and vector (no. 1) cell lines were treated with DMSO (white columns) or 1 μM rosiglitazone (black columns) for 6 h. mRNA levels of Fabp4 and Aqp7 were measured by quantitative RT-PCR. Averages and standard deviations relative to β-actin mRNA are shown from a representative experiment performed in triplicate. (B) Relative levels of p18/Cdkn2c and p27/Cdkn1b mRNA were determined in the same experiment.