Abstract
Of 50 strains of Escherichia coli isolated from blood cultures of bacteremic patients, 14 (28%) were unable to grow on minimal medium at 42 degrees C, compared to only 2 of 50 nonbacteremic strains. In 7 of the 14 bacteremic strains, growth at 42 degrees C was restored by adding nicotinic acid. These unique temperature-sensitive auxotrophic patterns warrant evaluation as a marker correlating with clinical pathogenicity in E. coli.
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- BACON G. A., BURROWS T. W., YATES M. The effects of biochemical mutation on the virulence of Bacterium typhosum; the loss of virulence of certain mutants. Br J Exp Pathol. 1951 Apr;32(2):85–96. [PMC free article] [PubMed] [Google Scholar]
- Foster J. W., Moat A. G. Nicotinamide adenine dinucleotide biosynthesis and pyridine nucleotide cycle metabolism in microbial systems. Microbiol Rev. 1980 Mar;44(1):83–105. doi: 10.1128/mr.44.1.83-105.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Garber E. D., Hackett A. J., Franklin R. The Virulence of Biochemical Mutants of Klebsiella Pneumoniae. Proc Natl Acad Sci U S A. 1952 Aug;38(8):693–697. doi: 10.1073/pnas.38.8.693. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Guze L. B., Montgomerie J. Z., Potter C. S., Kalmanson G. M. Pyelonephritis XVI. correlates of parasite virulence in acute ascending Escherichia coli pyelonephritis in mice undergoing diuresis. Yale J Biol Med. 1973 Jun;46(3):203–211. [PMC free article] [PubMed] [Google Scholar]
- Knapp J. S., Thornsberry C., Schoolnik G. A., Wiesner P. J., Homes K. K. Phenotypic and epidemiologic correlates of auxotype in Neisseria gonorrhoeae. J Infect Dis. 1978 Aug;138(2):160–165. doi: 10.1093/infdis/138.2.160. [DOI] [PubMed] [Google Scholar]
- Lachowicz T. M., Jankowski S., Lachowicz Z. Nutritional requirements of Shigella flexneri bacilli. 3. Nicotinic acid as a main growth factor of Sh. flexneri. Acta Microbiol Pol A. 1972;4(1):9–12. [PubMed] [Google Scholar]
- Ron E. Z., Davis B. D. Growth rate of Escherichia coli at elevated temperatures: limitation by methionine. J Bacteriol. 1971 Aug;107(2):391–396. doi: 10.1128/jb.107.2.391-396.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Spurgeon L., Thrupp L. D. Relation of virulence of Escherichia coli in septicemia and urinary tract infection to temperature-sensitive growth in minimal medium. J Infect Dis. 1980 Nov;142(5):773–773. doi: 10.1093/infdis/142.5.773. [DOI] [PubMed] [Google Scholar]