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. Author manuscript; available in PMC: 2010 Jun 15.
Published in final edited form as: Cancer Res. 2009 Jun 2;69(12):5115–5125. doi: 10.1158/0008-5472.CAN-09-0645

Fig.5. Correlation between epithelial and mesenchymal phenotype of liver metastases and Ad5/35 vectors transduction after intravenous injection.

Fig.5

Human tumor cells (HeLa, SK-Hep1, SAOS, or HT-29) were injected into the portal vein of immunodeficient mice. After liver metastases formed, mice received a tail vein injection of 2 × 109 pfu of Ad5/35 vectors expressing either GFP or βGal. Tumor-bearing livers were analyzed 3 days later for claudin 7 and transgene expression. HT-29 tumor bearing liver sections were also stained for CD31. For SK-Hep1 tumors, viral particles were visualized with an anti-hexon-FITC antibody at 2 hours post-injection.