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. 2009 Sep 16;4(9):e7011. doi: 10.1371/journal.pone.0007011

Figure 5. Structural diversity of TMH2 in the five template GPCRs.

Figure 5

A) tB1AR (blue) hB2AR (green) and bRHO (red) have similar conformations, with hAA2AR (purple) and sRHO (yellow) diverging at the extracellular end. B) sRHO has an insertion (Pro) relative to the other structures, which causes a bulge in the helix. The kink in hAA2AR may be accentuated due to the presence of a Cys residue forming a disulphide bridge with ECL2. C) Multidimensional scaling of the distances between TMH2 of the five template structures (distance is measured by RMSD [Table 6]). The stress value was 0.09. Colouring is the same as in A and B.