Skip to main content
. 2009 Sep 16;4(9):e7011. doi: 10.1371/journal.pone.0007011

Figure 6. Integrated workflows for template selection.

Figure 6

Shows the decision process for selecting which template should be used for modelling A) TMH1 B) TMH2 C) TMH3 D) TMH4 E) TMH5 F) TMH6 G) TMH7 and H) helix 8. For each helix the presence of particular features in a target GPCR are identified using a multiple sequence alignment with the five template GPCRs. Structural features include: a Gly-Gly bulge/distortion, a Pro distortion, insertions, disulphide bridges (SS-bridges), a Gly bend and sequence similarity to the helix extensions of sRHO. Where a target GPCR does not have any of the features then a template is chosen based on the sequence similarity score (seq sim).