Table 1. Characteristics of the 7 avian influenza (H5N1) isolates obtained in central People’s Republic of China, 2004*.
| HA titers | Avian |
Mammalian |
||||||
|---|---|---|---|---|---|---|---|---|
| EID50 | IVPI | ICPI | Pathogenicity in chickens† | TCID50 | MLD50 | Pathotype in mice‡ | ||
| EWHC |
210 |
107.5 |
3.0 |
1.91 |
High |
104.41 |
101.3 |
High |
| CKDW |
28 |
108.23 |
3.0 |
1.78 |
High |
107.8 |
102.3 |
High |
| GOZF |
28 |
109.8 |
2.98 |
1.88 |
High |
107.35 |
101.5 |
High |
| CKXF |
28 |
106.22 |
2.96 |
1.88 |
High |
104.67 |
106 |
Medium |
| CKJZ |
28 |
106.33 |
3.0 |
1.9 |
High |
105.24 |
>106.5 |
Low |
| CKTM |
28 |
107.23 |
1.71 |
1.36 |
High |
102.0 |
>106.5 |
Low |
| DKXF | 28 | 106.67 | 0 | 1.25 | Low | 106.57 | >106.5 | None |
*HA, hemagglutinin; EID50, 50% egg infectious dose; IVPI, intravenous pathogenicity index; ICPI, intracerebral pathogenicity index; TCID50, 50% tissue culture infectious dose;; MLD50, 50% lethal dose in mice; EWHC, A/widgeon/Hubei/EWHC/2004; CKDW, A/chicken/Hubei/327/2004; GOZF, A/goose/Hubei/ZFE/2004; CKXF, A/chicken/Hubei/XFJ/2004; CKJZ, A/chicken/Hubei/JZJ/2004; CKTM, A/chicken/Hubei/TMJ/2004; DKXF, A/duck/Hubei/XFY/2004. †Avian influenza virus isolates are considered to be highly pathogenic if they cause a death rate of >75% within 10 days or have an IVPI of >1.2 (World Organization for Animal Health criteria). ‡The pathotypes in mice were divided into none, low (MLD50>6.5 log10EID50), medium (3.0 log10EID50<MLD50≤6.5 log10EID50), and high (MLD50≤3.0 log10EID50).