Table 4. Antibody response of adult golden hamsters to intramuscular inoculation of 1.8 X 106 of ChimeriVax–WNV and subsequent challenge with WNV (104.0 TCID50 given intraperitoneally)a.
Animal no. |
HI antibody titer |
CF antibody titer |
WNV PRN
antibody
titerb |
||
---|---|---|---|---|---|
YFV
antigen |
WNV
antigen |
YFV
antigen |
WNV
antigen |
||
31 days after ChimeriVax-WNV | |||||
H-8183 | 1:40 | 1:160 | 0c | 0 | 1:160 |
H-8184 | 1:40 | 1:160 | 0 | ND | 1:160 |
H-8185 | 1:40 | 1:160 | 0 | 1:20 | 1:640 |
H-8186 | 1:80 | 1:320 | 0 | 1:40 | 1:320 |
H-8187 | 1:40 | 1:160 | 0 | 1:20 | >1:640 |
H-8188 | 1:40 | 1:160 | 0 | 1:20 | 1:640 |
H-8189 | 1:80 | 1:320 | 0 | 1:40 | 1:640 |
H-8190 | 1:40 | 1:160 | 0 | 1:20 | 1:320 |
H-8191 | 1:80 | 1:160 | 0 | 1:20 | 1:80 |
H-8192 | 1:40 | 1:160 | 0 | 1:40 | 1:80 |
6 days after challenge with WNV | |||||
H-8183 | 1:20 | 1:160 | 0 | 0 | ND |
H-8184 | 1:40 | 1:160 | 0 | 1:40 | ND |
H-8185 | 1:20 | 1:160 | 0 | 1:20 | ND |
H-8186 | 1:80 | 1:320 | 0 | 1:40 | ND |
H-8187 | 1:20 | 1:160 | 0 | 1:20 | ND |
H-8188 | 1:40 | 1:160 | 0 | 1:20 | ND |
H-8189 | 1:80 | 1:320 | 0 | 1:40 | ND |
H-8190 | 1:40 | 1:320 | 0 | 1:40 | ND |
H-8191 | 1:40 | 1:320 | 0 | 1:20 | ND |
H-8192 | 1:40 | 1:160 | 0 | 1:20 | ND |
aWNV, West Nile virus; HI, hemagglutination inhibition; CF, complement fixation; PRN, plaque reduction neutralization; YFV, Yellow fever virus; ND, not done. bHighest serum dilution producing >90% plaque inhibition. c0 = <1:20.