Table 5. Antibody response of adult golden hamsters to intramuscular inoculation of 1.8 X 103 of ChimeriVax-WNV and WNV104.0 TCID50 given intraperitoneallya.
Animal no. |
HI antibody titer |
CF antibody titer |
WNV PRN
antibody
titerb |
|||
---|---|---|---|---|---|---|
YFV
antigen |
WNV
antigen |
YFV
antigen |
WNV
antigen |
|||
32 days after ChimeriVax-WNV | ||||||
H-8322 | 1:40 | 1:160 | 0c | 1:20 | 1:320 | |
H-8323 | 1:20 | 1:80 | 0 | 1:40 | 1:160 | |
H-8324 | 1:80 | 1:320 | 1:20 | 1:80 | 1:160 | |
H-8325 | 1:40 | 1:320 | 0 | 1:80 | ≥ 1:640 | |
H-8326 | 1:40 | 1:320 | 0 | 1:80 | 1:320 | |
H-8327 | 1:40 | 1:320 | ND | ND | 1:320 | |
H-8328 | 1:80 | 1:320 | 1:20 | 1:80 | 1:80 | |
H-8329 | 1:40 | 1:320 | 0 | 1:80 | 1:80 | |
7 days after challenge with WNV | ||||||
H-8322 | 1:40 | 1:320 | 0 | 1:20 | ND | |
H-8323 | 1:40 | 1:160 | 0 | 1:20 | ND | |
H-8324 | 1:80 | 1:320 | 0 | 1:40 | ND | |
H-8325 | 1:80 | 1:320 | 0 | 1:80 | ND | |
H-8326 | 1:80 | 1:320 | 0 | 1:40 | ND | |
H-8327 | 1:40 | 1:160 | 0 | 1:20 | ND | |
H-8328 | 1:80 | 1:320 | 0 | 1:40 | ND | |
H-8329 | 1:40 | 1:320 | 0 | 1:80 | ND |
aWNV, West Nile virus; HI, hemagglutination inhibition; CF, complement fixation; PRN, plaque reduction neutralization; YFV, Yellow fever virus; ND, not done. bHighest serum dilution producing >90% plaque inhibition. c0 = <1:20.