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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Biochim Biophys Acta. 2008 Aug 3;1778(11):2469–2479. doi: 10.1016/j.bbamem.2008.07.024

Fig. 1.

Fig. 1

Peptides block RyR2 in a voltage-dependent manner. Mean open probability (Po) of RyR2 channels as a function of holding voltage (Vm) ranging from −30 mV to +40 mV (trans - cis). RyR2 channels were fully activated by the combined action of Ca2+ (10 µM) and caffeine (5 mM) in their cytosolic (cis) surface. Lumenal (trans) Ca2+ (50 mM) was the current carrier. Po's are mean values from n = 15 (control; filled circles), 4 (Peptide A, open squares), 6 (Shaker B, open diamonds) and 6 (KIFMK; open triangles). Values are shown as mean ± SEM. Lines represent fits of the Woodhull equation to experimental data (see Results).