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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Biochim Biophys Acta. 2008 Aug 3;1778(11):2469–2479. doi: 10.1016/j.bbamem.2008.07.024

Fig. 5.

Fig. 5

Imperatoxin modifies kinetics of RyR2 block by KIFMK. (A) Single-channel recordings of RyR2 with Ca2+/caffeine and IpTxA (50 nM) at Vm = +10 mV. Traces under control conditions (left) and after addition of 500 µM KIFMK (right) are shown. (B) Dwell times of KIFMK block. (C) Number of block events and (D) Probability of block (Pblock). Parameters of KIFMK block were estimated during segments of full openings (black bars) and during imperatoxin-induced substates (grey bars). * p < 0.05, n=5 paired observations.