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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Biochim Biophys Acta. 2008 Aug 3;1778(11):2469–2479. doi: 10.1016/j.bbamem.2008.07.024

Fig. 6.

Fig. 6

Peptide A increases the probability of the Ryanodol substate. (A) Single-channel recordings of a RyR2 in the presence of Ryanodol (20 µM) before and after addition of 5 µM Peptide A (Vm = 0 mV). "R" represents openings to the ryanodol-induced subconductance state. The temporarily expanded traces (lower panels) evidence that Peptide A action is different during full openings vs. ryanodol-induced substates. (B) Probability (Psubstate; black bars) and dwell time (grey bars) of ryanodol-induced substates before and after addition of Peptide A. * p < 0.05, n=5 paired observations.