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. Author manuscript; available in PMC: 2010 Jul 28.
Published in final edited form as: Brain Res. 2009 Jun 2;1282:10–19. doi: 10.1016/j.brainres.2009.05.061

Figure 1.

Figure 1

CCK depolarizes layer 6b neurons. A: Left: Low power image of somatosensory cortex in coronal slice. Layer 6b can be identified from the image above white matter. Right: Biocytin-filled morphologies representative of layer 5, 6a and 6b neurons. B: i. In a current clamp recording from a layer 6b neuron in control conditions, CCK8S (1.25 μM, 60 seconds) depolarizes the membrane leading to action potential discharge. The short downward deflections are voltage responses to short hyperpolarizing current pulses (−15 pA, 500 ms). The prolonged hyperpolarization to baseline levels is produced by adding hyperpolarizing current and serves to determine voltage-independent alterations in the transient hyperpolarizing steps. ii. Voltage responses and firing pattern to the hyperpolarizing and depolarizing DC current steps to the neuron.