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. Author manuscript; available in PMC: 2010 Jul 28.
Published in final edited form as: Brain Res. 2009 Jun 2;1282:10–19. doi: 10.1016/j.brainres.2009.05.061

Figure 4.

Figure 4

Selective CCKB agonist depolarizes layer 6b neurons. A: CCK4 (1.25 μM) was applied two times with a 30 min interval. The second response was smaller than the first response (Ai & Aii). Aiii: The average ratio of the second response amplitude to the first response amplitude was 78 ± 11% (n=10). B: The effects of CCK4 were not blocked in the presence of CCKA antagonist L364718 (1 μM). The average ratio of the second response amplitude to the first response amplitude was 74 ± 6% (n=5). C: In contrast, CCKB antagonist L365260 (1 μM) completely attenuated the actions of CCK4. The average ratio of the second response amplitude to the first response amplitude was 17 ± 10% (n=5). D: The slopes of control, CCKA antagonist, and CCKB antagonist were 0.38, 0.66, and −0.02. The slope of CCKB antagonist differed significantly from the control and CCKA antagonist regressions. The dashed line indicates the slope of 1. All experiments were done in TTX.