Fig. 2.

Pronounced helical bending in phosphorylated DesKC. (A) The pattern of intrahelical H bonds in monomer A of DesKC-P (Top) and E188a (Bottom) around the phosphorylatable histidine is modified as a consequence of a helical bulge, facilitated by the presence of a conserved glycine (G192). Note that the carbonyl oxygen of D189 (arrow) is not involved in H bond interactions. Other side-chains are omitted for clarity. (B) Close view of the interaction between helix α1 and the ABD from the opposite monomer in E188a.