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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: Fertil Steril. 2008 Jul 30;91(6):2650–2663. doi: 10.1016/j.fertnstert.2008.03.071

Table 1.

Differentially expressed genes in leiomyomata categorized by the indicated functional groups based on published reports. Multiple entries reflect different probe sets for a given target. Genes are listed in order of magnitude of fold change relative to normal myometrium. Negative values indicate down regulated genes.

Proapoptotic genes
Genbank Description Fold Gene Symbol
AF344882 Mst3 and SOK1-related kinase −31.55 MST4
NM_016542 Mst3 and SOK1-related kinase −22.72 MST4
NM_002583 PRKC, apoptosis, WT1, regulator −2.84 PAWR
NM_004938 Death-associated protein kinase 1 −2.34 DAPK1
AF356193 Caspase recruitment domain family 6 −2.28 CARD6
BF434846 Tenascin C (hexabrachion) −4.80 TNC
NM_006307 Sushi-repeat-containing protein, X-linked −2.04 SRPX
AI281371 APO-1/CD95 (Fas)-associated phosphatase −3.98 PTPN13
NM_006264 APO-1/CD95 (Fas)-associated phosphatase −2.39 PTPN13
AW770896 Insulin-like growth factor binding protein 7 −2.30 IGFBP7
NM_002184 IL6 signal transducer (oncostatin M receptor) −4.71 IL6ST
AW242916 IL6 signal transducer (oncostatin M receptor) −2.05 IL6ST
AB015706 IL6 signal transducer (oncostatin M receptor) −2.05 IL6ST
NM_002135 Nuclear receptor subfamily 4A1 −2.02 NR4A1
BC002439 HIV-1 Tat interactive protein 2, 30kDa −2.86 HTATIP2
BF511276 A kinase anchor protein (gravin) 12 −2.75 AKAP12
BF511276 A kinase anchor protein (gravin) 12 −2.42 AKAP12
AB003476 A kinase anchor protein (gravin) 12 −2.19 AKAP12
U57059 TNF-related apoptosis inducing ligand TRAIL −2.17 TNFSF10
NM_004226 Ser/thr kinase 17b (apoptosis-inducing) −3.96 STK17B
AA203487 Ser/thr kinase 17b (apoptosis-inducing) −2.26 STK17B
NM_021730 CARD7, DEFCAP 2.18 NALP1
AF003934 Growth differentiation factor 15 5.23 GDF15
Growth promoting genes
Genbank Description Fold Gene Symbol
NM_003294 Tryptase alpha/beta 1 2.02 TPSAB1
NM_001897 Chondroitin sulfate proteoglycan 4 2.32 CSPG4
NM_002997 Syndecan 1 2.26 SDC1
AV694854 Adrenergic, alpha-1A-, receptor 3.01 ADRA1A
N51516 Adrenergic, alpha-1A-, receptor 2.53 ADRA1A
AJ000008 Phosphoinositide-3-kinase, gamma 2.87 PIK3C2G
BC003105 Protein tyrosine phosphatase type IVA, 3 2.05 PTP4A3
X99268 Twist homolog 1 2.17 TWIST1
NM_000612 Insulin-like growth factor 2 (somatomedin A) 5.67 IGF2
M17863 Insulin-like growth factor 2 (somatomedin A) 3.55 IGF2
J03241 Transforming growth factor, beta 3 2.37 TGFB3
NM_002738 Protein kinase C, beta 1 4.90 PRKCB1
M13975 Protein kinase C, beta 1 2.98 PRKCB1
M73554 Cyclin D1 (PRAD1) 2.74 CCND1
NM_001759 Cyclin D2 2.06 CCND2
NM_005195 CCAAT/enhancer binding protein delta −2.07 CEBPD
NM_002039 GRB2-associated binding protein 1 −2.24 GAB1
Growth inhibitory genes
Genbank Description Fold Gene Symbol
AI281593 Decorin −2.45 DCN
AF138303 Decorin −2.09 DCN
AI343467 Inhibin, beta A (activin A, activin AB alpha) −3.99 INHBA
M13436 Inhibin, beta A (activin A, activin AB alpha) −3.17 INHBA
NM_002036 Duffy blood group −2.95 DARC
AA530892 Dual specificity phosphatase 1 (MKP-1) −2.63 DUSP1
AW770896 Insulin-like growth factor binding protein 7 −2.30 IGFBP7
AF493929 Regulator of G-protein signalling 5 −2.18 RGS5
AI183997 Regulator of G-protein signalling 5 −2.07 RGS5
AF132818 Kruppel-like factor 5 −5.05 KLF5
AF003114 Cysteine-rich, angiogenic inducer, 61 −8.12 CYR61
NM_001554 Cysteine-rich, angiogenic inducer, 61 −6.59 CYR61
AA150501 Epithelial membrane protein 1 −2.32 EMP1
BE552421 Mitochondrial tumor suppressor 1 −2.22 MTUS1
AW444761 Cyclin-dependent kinase inhibitor 2B (p15) −3.41 CDKN2B
NM_022470 P53 target zinc finger protein 2.29 ZMAT3
Putative Tumor Suppressor genes
Genbank Description Fold Gene Symbol
L16895 Lysyl oxidase −2.61 LOX
NM_002317 Lysyl oxidase −2.31 LOX
AF101051 Claudin 1 −13.02 CLDN1
NM_021101 Claudin 1 −5.33 CLDN1
NM_006307 Sushi-repeat-containing protein, X-linked −2.04 SRPX
M92934 Connective tissue growth factor −3.34 CTGF
NM_006207 Platelet-derived growth factor receptor-like −2.67 PDGFRL
NM_012307 Erythrocyte membrane protein band 4.1-like 3 −2.00 EPB41L3
BE552421 Mitochondrial tumor suppressor 1 −2.22 MTUS1
NM_003206 Transcription factor 21 −11.05 TCF21
AF055585 Slit homolog 2 −3.00 SLIT2
AI692523 Slit homolog 2 −2.95 SLIT2
AI963304 Slit homolog 2 −2.36 SLIT2
AI343467 Inhibin, beta A (activin A, activin AB alpha) −3.99 INHBA
M13436 Inhibin, beta A (activin A, activin AB alpha) −3.17 INHBA
AF017987 Secreted frizzled-related protein 1 −2.28 SFRP1
AI332407 Secreted frizzled-related protein 1 −2.07 SFRP1
NM_003012 Secreted frizzled-related protein 1 −2.02 SFRP1
U16153 Inhibitor of DNA binding 4 −2.58 ID4
AW157094 Inhibitor of DNA binding 4 −3.47 ID4
NM_013253 Dickkopf homolog 3 −2.26 DKK3
AU148057 Dickkopf homolog 3 −2.23 DKK3
NM_002318 Lysyl oxidase-like 2 2.74 LOXL2
U17074 Cyclin-dependent kinase inhibitor 2C (p18) 2.63 CDKN2C
NM_001262 Cyclin-dependent kinase inhibitor 2C (p18) 2.63 CDKN2C
Genes associated with invasion, migration or metastasis
Genbank Description Fold Gene Symbol
AF101051 Claudin 1 −13.02 CLDN1
NM_021101 Claudin 1 −5.33 CLDN1
NM_004938 Death-associated protein kinase 1 −2.34 DAPK1
NM_006614 Cell adhesion molecule with homology to L1CAM −24.44 CHL1
BF434846 Tenascin C (hexabrachion) −4.80 TNC
AL552534 CD44 antigen −2.71 CD44
AF098641 CD44 antigen −2.40 CD44
M24915 CD44 antigen −2.38 CD44
NM_000610 CD44 antigen −2.32 CD44
AI493245 CD44 antigen −2.13 CD44
BC004372 CD44 antigen −2.12 CD44
J05021 Villin 2 (ezrin) −2.22 VIL2
AA670344 Villin 2 (ezrin) −2.19 VIL2
AL574210 Serine proteinase inhibitor, PAI 1 −3.73 SERPINE1
U66495 Leptin receptor −2.48 LEPR
U08626 Leptin receptor −2.46 LEPR
AI308863 Leptin receptor −2.05 LEPR
NM_000956 Prostaglandin E receptor 2 (subtype EP2) −2.25 PTGER2
NM_003882 WNT1 inducible signaling pathway protein 1 −2.48 WISP1
AA147884 WNT1 inducible signaling pathway protein 1 −2.07 WISP1
AI917494 WNT1 inducible signaling pathway protein 1 −2.07 WISP1
NM_007003 P antigen family, member 4 −3.07 PAGE4
NM_001993 Coagulation factor III (tissue factor) −4.21 F3
NM_002010 Fibroblast growth factor 9 −5.19 FGF9
AI520969 Vimentin −2.08 VIM
AF344882 Mst3 and SOK1-related kinase −31.55 MST4
NM_016542 Mst3 and SOK1-related kinase −22.72 MST4
AA749101 Interferon induced transmembrane protein 1 −2.14 IFITM1
NM_002276 Keratin 19 −11.30 KRT19
NM_002423 Matrix metalloproteinase 7 (matrilysin) −4.37 MMP7
AI417595 Endomucin −2.94 EMCN
AI635774 Endomucin −2.07 EMCN
AI281371 APO-1/CD95 (Fas)-associated phosphatase −3.98 PTPN13
NM_006264 APO-1/CD95 (Fas)-associated phosphatase −2.39 PTPN13
AI189753 Human tumor antigen (L6), TAAL6 −2.26 TM4SF1
M90657 Human tumor antigen (L6), TAAL6 −2.71 TM4SF1
U76833 Fibroblast activation protein, alpha −2.30 FAP
L01639 Chemokine (C-X-C motif) receptor 4 −2.21 CXCR4
AF348491 Chemokine (C-X-C motif) receptor 4 −2.06 CXCR4
D13889 Inhibitor of DNA binding 1, Id1 −2.98 ID1
AF003114 Cysteine-rich, angiogenic inducer, 61 −8.12 CYR61
NM_001554 Cysteine-rich, angiogenic inducer, 61 −6.59 CYR61
AL136139 Enhancer of Filamentation 1 −2.50 HEF1
NM_004995 Matrix metalloproteinase 14 2.65 MMP14
Z48481 Matrix metalloproteinase 14 2.21 MMP14
X83535 Matrix metalloproteinase 14 2.06 MMP14
NM_005940 Matrix metalloproteinase 11 (stromelysin 3) 7.58 MMP11
AI761713 Matrix metalloproteinase 11 (stromelysin 3) 3.80 MMP11
X99268 Twist homolog 1 2.17 TWIST1