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. Author manuscript; available in PMC: 2010 Mar 1.

Published in final edited form as: Epilepsy Res. 2009 Jan 29;84(1):42–55. doi: 10.1016/j.eplepsyres.2008.12.005

(A) Summed Layer II/III pyramidal cell action potentials in 10 msec bins, with superimposed stimulation-induced quiescent periods. The time interval between the second and third pulses of the three-pulse paradigm is demonstrated by the position of the quiescent period value. These quiescent periods induced by the stop pulse demonstrate a phase dependence with respect to the underlying activity. Also shown are the details of network activity occurring during the three periods of loss of stimulation efficacy at 0.12, 0.98−1.0, and 2.29−2.31 seconds into the constant bursting period (Layer II/III pyramidal cell activity). At 0.12 sec, 0.98 sec, and 2.29 sec, the activity does exhibit a period of quiescence, albeit delayed, with the presence of a single pulse of activity in the normally quiet post-stimulation window. The “sawtooth” region described in the text is demonstrated by the quiescence time peaks in red primarily between 1.0−3.0 seconds. (B) Similar plot demonstrating quiescent periods shown with the underlying network MFP.

(A) Summed Layer II/III pyramidal cell action potentials in 10 msec bins, with superimposed stimulation-induced quiescent periods. The time interval between the second and third pulses of the three-pulse paradigm is demonstrated by the position of the quiescent period value. These quiescent periods induced by the stop pulse demonstrate a phase dependence with respect to the underlying activity. Also shown are the details of network activity occurring during the three periods of loss of stimulation efficacy at 0.12, 0.98−1.0, and 2.29−2.31 seconds into the constant bursting period (Layer II/III pyramidal cell activity). At 0.12 sec, 0.98 sec, and 2.29 sec, the activity does exhibit a period of quiescence, albeit delayed, with the presence of a single pulse of activity in the normally quiet post-stimulation window. The “sawtooth” region described in the text is demonstrated by the quiescence time peaks in red primarily between 1.0−3.0 seconds. (B) Similar plot demonstrating quiescent periods shown with the underlying network MFP.