Table A1.
TIP Regimen and Definition of Dose Reduction Levels
| Agent | Day | Starting Dose (mg/m2) |
|||
|---|---|---|---|---|---|
| −3 | −2 | −1 | 0 | ||
| Paclitaxel | 1 | 85 | 110 | 135 | 175 |
| Cisplatin | 1 | 50 | 60 | 60 | 60 |
| Ifosfamide | 1-3 | 1,000 | 1,000 | 1,000 | 1,000 |
| Mesna | 1-3 | 720 | 720 | 720 | 720 |
NOTE. Patients received three to four cycles of TIP chemotherapy (paclitaxel 175 mg/m2 on day 1; ifosfamide 1,000 mg/m2 on days 1 to 3; and cisplatin 60 mg/m2 on day 1). Patients were premedicated with dexamethasone, cimetidine, and diphenhydramine before paclitaxel, which was administered intravenously over 3 hours by continuous infusion in a single dose. Ifosfamide was administered intravenously over 2 hours on days 1 to 3. Mesna was administered to reduce the incidence of hemorrhagic cystitis and hematuria. Cisplatin was administered intravenously over 2 hours on day 1 after completion of paclitaxel infusion. Treatment courses were repeated every 21 days or when blood counts recovered and nonhematologic toxicity resolved.
Abbreviation: TIP, paclitaxel, ifosfamide, and cisplatin.