Table 1.
Demographics of the CCSS Cohort and Subsets Based on the Development of Subsequent Neoplasms
| Characteristic | CCSS Cohort |
Cohort Subsets Based on SNs |
||||||
|---|---|---|---|---|---|---|---|---|
| SMN |
NMSC Only |
No SN |
||||||
| No. | % | No. | % | No. | % | No. | % | |
| No. of patients | 14,358 | 730 | 430 | 13,198 | ||||
| Age at diagnosis, years | ||||||||
| Mean | 8.3 | 11.0 | 11.8 | 8.0 | ||||
| Median | 6.8 | 12.1 | 12.9 | 6.4 | ||||
| Sex | ||||||||
| Male | 7,714 | 53.7 | 287 | 39.3 | 218 | 50.7 | 7,209 | 54.6 |
| Female | 6,644 | 46.3 | 443 | 60.7 | 212 | 49.3 | 5,989 | 45.4 |
| Race | ||||||||
| White | 12,396 | 86.3 | 665 | 91.1 | 413 | 96.0 | 11,318 | 85.8 |
| Black | 694 | 4.8 | 23 | 3.2 | 1 | 0.2 | 670 | 5.1 |
| Other | 1,217 | 8.5 | 39 | 5.3 | 13 | 3.0 | 1,165 | 8.8 |
| Unknown | 51 | 0.4 | 3 | 0.4 | 3 | 0.7 | 45 | 0.3 |
| Primary diagnosis | ||||||||
| Leukemia | 4,829 | 33.6 | 152 | 20.8 | 138 | 32.1 | 4,539 | 34.4 |
| CNS tumor | 1,877 | 13.1 | 68 | 9.3 | 40 | 9.3 | 1,769 | 13.4 |
| HL | 1,927 | 13.4 | 247 | 33.8 | 163 | 37.9 | 1,517 | 11.5 |
| NHL | 1,081 | 7.5 | 43 | 5.9 | 27 | 6.3 | 1,011 | 7.7 |
| Wilms tumor | 1,256 | 8.7 | 33 | 4.5 | 13 | 3.0 | 1,210 | 9.2 |
| Neuroblastoma | 955 | 6.7 | 33 | 4.5 | 6 | 1.4 | 916 | 6.9 |
| Soft tissue sarcoma | 1,245 | 8.7 | 80 | 11.0 | 23 | 5.3 | 1,142 | 8.7 |
| Bone cancer | 1,188 | 8.3 | 74 | 10.1 | 20 | 4.7 | 1,094 | 8.3 |
| Chemotherapy | 12,575 | 669 | 395 | 11,511 | ||||
| Alkylating agents | 6,545 | 52.0 | 393 | 58.7 | 195 | 49.4 | 5,957 | 51.8 |
| Anthracyclines | 4,966 | 39.5 | 255 | 38.1 | 108 | 27.3 | 4,603 | 40.0 |
| Epipodophyllotoxins | 990 | 7.9 | 35 | 5.2 | 21 | 5.3 | 934 | 8.1 |
| Platinum agents | 666 | 5.3 | 26 | 3.9 | 6 | 1.5 | 634 | 5.5 |
| Radiation therapy | 8,412 | 67.0 | 550 | 82.3 | 367 | 92.7 | 7,495 | 65.2 |
| Splenectomy | 1,230 | 9.8 | 173 | 25.9 | 123 | 31.2 | 934 | 8.1 |
Abbreviations: CCSS, Childhood Cancer Survivor Study; SMN, second malignant neoplasm; NMSC, nonmelanoma skin cancer; SN, subsequent neoplasm; HL, Hodgkin's lymphoma; NHL, non-Hodgkin's lymphoma.