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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Biochim Biophys Acta. 2009 Mar 11;1794(9):1355–1363. doi: 10.1016/j.bbapap.2009.02.015

Figure 1. λN protein sequence and cleavage profile by E. coli Lon (10).

Figure 1

The λN protein is an intrinsically unstructured endogenous protein substrate of E. coli Lon. It has seven major Lon cleavage sites as indicated by the arrows. The amino acids that make up the FRETN89-98 peptide are highlighted in the rectangle. The underlined A-Q pairs highlight the lack of specificity of Lon, in that the amino acid residues flanking the scissile site alone do not warrant peptide bond cleavage, as 16A-17Q but not 3A-4Q was selectively cleaved by E.coli Lon.