Table 4.
Allelic odds ratios and 95% confidence intervals for comparison of TNF-α variants with IBD status in New Zealand IBD patients and Caucasians
|
TNF-α_361525 (-238 G/A) |
TNF-α_1799724 (-857C/T) |
TNF-α_1800629 (-308 G/A) |
||||||||||
| CD | UC | CD | UC | Crohn's | UC | |||||||
| OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI | |
| Female | 1.00 | 0.59-1.69 | 0.64 | 0.35-1.18 | 1.06 | 0.65-1.74 | 1.07 | 0.64-1.79 | 1.01 | 0.72-1.41 | 1.19 | 0.85-1.67 |
| Male | 1.29 | 0.69-2.41 | 1.15 | 0.63-2.08 | 1.08 | 0.62-1.89 | 1.46 | 0.84-2.53 | 1.26 | 0.85-1.87 | 1.34 | 0.93-1.93 |
| Age at first diagnosis | ||||||||||||
| 0-16 yr | 1.30 | 0.54-3.14 | 0.31 | 0.04-2.29 | 1.67 | 0.51-5.48 | 0.8 | 0.28-2.31 | 1.66 | 0.97-2.85 | 1.60 | 0.83-3.07 |
| 17-40 yr | 0.92 | 0.55-1.54 | 0.8 | 0.46-1.39 | 0.85 | 0.53-1.36 | 0.75 | 0.47-1.20 | 1.01 | 0.74-1.39 | 1.23 | 0.90-1.68 |
| > 40 yr | 1.30 | 0.78-2.17 | 1.02 | 0.62-1.69 | 0.72 | 0.44-1.18 | 1.31 | 0.76-2.25 | 1.08 | 0.77-1.52 | 1.26 | 0.93-1.71 |
| CD location | ||||||||||||
| Ileal | 0.93 | 0.51-1.71 | 0.98 | 0.55-1.75 | 1.00 | 0.69-1.45 | ||||||
| Colonic | 1.09 | 0.65-1.83 | 1.00 | 0.59-1.69 | 1.25 | 0.91-1.72 | ||||||
| Ileocolonic | 1.44 | 0.79-2.63 | 0.56 | 0.32-0.97 | 0.92 | 0.59-1.42 | ||||||
| UC location | ||||||||||||
| Proctitis | 1.07 | 0.61-1.87 | 0.68 | 0.41-1.12 | 0.90 | 0.62-1.30 | ||||||
| Left colon | 0.76 | 0.38-1.52 | 1.36 | 0.68-2.73 | 0.97 | 0.65-1.45 | ||||||
| Pancolitis | 0.74 | 0.40-1.36 | 1.08 | 0.62-1.88 | 1.91 | 1.41-2.60 | ||||||
| CD Behaviour | ||||||||||||
| Inflammatory | 1.27 | 0.81-2.00 | 1.05 | 0.64-1.71 | 1.19 | 0.89-1.60 | ||||||
| Structuring | 1.19 | 0.67-2.10 | 0.66 | 0.39-1.11 | 1.01 | 0.69-1.47 | ||||||
| Penetrating | 0.16 | 0.02-1.17 | 0.65 | 0.31-1.37 | 0.89 | 0.50-1.59 | ||||||
| Ileal/Structuring | 1.34 | 0.70-2.58 | 0.95 | 0.47-1.92 | 1.04 | 0.66-1.64 | ||||||
| Colonic/Inflammatory | 1.29 | 0.77-2.17 | 1.06 | 0.60-1.87 | 1.29 | 0.92-1.80 | ||||||
| TNF-α_361525 (-238 G/A) | TNF-α_1799724 (-857C/T) | TNF-α_1800629 (-308 G/A) | ||||||||||
| Any relative with IBD | 1.15 | 0.57-2.32 | 0.89 | 0.39-2.01 | 1.02 | 0.49-2.12 | 1.02 | 0.47-2.20 | 1.49 | 0.98-2.27 | 0.98 | 0.60-1.60 |
| Bowel resection | 1.12 | 0.65-1.93 | 0.7 | 0.29-1.66 | 0.59 | 0.37-0.95 | 0.97 | 0.47-2.02 | 0.93 | 0.65-1.34 | 1.57 | 1.02-2.41 |
| Smoker at diagnosis | 1.04 | 0.54-1.99 | 0.66 | 0.23-1.87 | 1.00 | 0.52-1.91 | 0.48 | 0.25-0.94 | 0.84 | 0.54-1.30 | 1.08 | 0.63-1.86 |
| Ever used immunomodulators | 1.07 | 0.66-1.75 | 0.66 | 0.29-1.48 | 0.93 | 0.57-1.51 | 0.75 | 0.41-1.39 | 1.09 | 0.80-1.48 | 1.46 | 0.98-2.17 |
| Any EIMs | 1.11 | 0.55-2.24 | 0.5 | 0.18-1.41 | 1.60 | 0.67-3.80 | 2.07 | 0.74-5.83 | 1.46 | 0.96-2.22 | 1.28 | 0.81-2.03 |