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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: Cell Res. 2009 Jun;19(6):672–682. doi: 10.1038/cr.2009.56

Figure 1.

Figure 1

Adult NSCs in the SVZ and SGZ of the mammalian brain. (A) A schematic illustration of the adult mammalian brain in mice. Adult NSCs are primarily present in two germinal regions: the subventricular zone (SVZ) of the lateral ventricle wall and the subgranular zone (SGZ) of the hippocampal dentate gyrus. (B). Adult NSCs in the SVZ. Quiescent or dormant adult SVZ NSCs (dNSC) correspond to a unique type of cell population with cell bodies in the SVZ while contacting the ventricle through apical surfaces. They also share several common features of GFAP+ astrocytes and CD133+ ependymal cells. Actively self-renewing adult SVZ NSCs (sNSC) are located in the SVZ and give rise to neuroblasts that migrate toward the olfactory bulb. (C) Adult NSCs in the SGZ. Quiescent or dormant adult SGZ NSCs correspond to radial glia-like cells, some of which might transit to actively self-renewing adult SGZ NSCs and give rise to neuroblasts (NB) and newly generated neurons (NGN).