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. Author manuscript; available in PMC: 2010 Feb 15.
Published in final edited form as: Transplantation. 2009 Feb 15;87(3):360–369. doi: 10.1097/TP.0b013e31819574e9

Figure 4.

Figure 4

AMG1237845 does not alter allograft-driven CD8 T cell proliferation. Ld-reactive 2C TCR transgenic CD8 T cells (B6 background) were labeled with CFSE and 8×106 were adoptively transferred to allograft recipients on day -1. Mice received Ld-expressing A/J heart grafts and were treated with vehicle or AMG1237845 until grafts and spleens were harvested on day +5. CFSE dilution was monitored by flow cytometry. Flow plots are representative of 5-6 mice per group. The percent of splenic and graft-infiltrating 2C T cells dividing is shown and is not statistically different between the two treatment groups at the 95% confidence interval.