Table 2. Thermal stability, mean residual ellipticity at 225 nm and calorimetric enthalpy values for peptides containing a G1G interruption and homologous control peptides, in PBS (pH 7).
Peptide | Peptide Sequence | Tm | MRE225nm | ΔHcal |
---|---|---|---|---|
Name | (°C) | (deg cm2 dmol-1) | (kJ/mol) | |
GF a | (GPO)3GPOG*F*GPO(GPO)2G*POGPOGYb | 21 | 2950 | 100 |
GFO a | (GPO)3GPOGFOGPO(GPO)4GY | 44 | 5500 | 221 |
GY | Ac-(GPO)3GPOGYGPQ(GPO)4G-NH2 | 26.5 | 3966 | 310 |
GYO | Ac-(GPO)3GPOGYOGPQ(GPO)4G-NH2 | 48.5 | 5120 | 357 |
GP | (POG)3POGPGPO(GPO)4G | <5 (15c) | n.a | n.a |
GPO | (POG)10 | 58 | 4012 | 390 |
GV | Ac-(GPO)3GPOGAAGVGPO(GPO)3GY-NH2 | 27.5 | 3006 | 187 |
GAAVM d | Ac-(GPO)3GPOGAAVMGPO(GPO)3GY-NH2 | 29.1 | 2360 | 188 |
GAAGVM | Ac-(GPO)3GPOGAAGVMGPO(GPO)3GY-NH2 | 39.7 | 4950 | 354 |