Table 2.

Laboratory data and selectivity index for patients included in the selectivity index analysis in Kenya and Mali^*

	No.	Age (months)	Hb (g/dL)	Parasitemia† (%)	WBC (× 109/L)	Rosette frequency‡	Selectivity index (geometric mean (95% CI))
Kenya
All patients	98	33 (26) [79]	8.1 (2.5) [74]	6.5 (6.1)	13.2 (13.1) [45]	4.25 (1–13.5) [62]	1.92 (1.65–2.19)
Uncomplicated	52	40 (27) [37]	9.4 (1.5) [32]	4.2 (2.9)	9.0 (3.9) [21]	1.5 (0–7) [31]	2.05 (1.55–2.55)
Severe§	46	27 (23) [42]	7.0 (2.6) [42]	9.0 (7.7)	16.9 (16.9) [24]	6.5 (2.5–17.5) [31]	1.79 (1.58–2.01)
P		0.022	< 0.0001	< 0.0001	0.044	0.009	0.56
Mali
All patients	104	39 (24)	9.0 (2.4)	7.6 (7.0)	13.9 (7.7) [101]	12 (2–22) [98]	1.61 (1.12–2.10)
Uncomplicated	33	38 (20)	9.4 (1.7)	3.3 (2.5)	12.9 (6.3) [32]	2 (0–14.5)	1.86 (0.60–3.11)
Severe	46	38 (25)	8.2 (2.9)	6.9 (5.7)	15.4 (9.3) [45]	18.5 (11.5–37) [40]	1.55 (0.86–2.25)
Hyperparasitemic	25	44 (25)	10.2 (1.5)	14.8 (8.0)	12.3 (5.5) [24]	5 (2–19.5)	1.44 (1.21–1.67)
P		0.58	0.003	< 0.0001	0.19	< 0.0001	0.62

^*Values are the mean (SD) or median (interquartile range) unless otherwise indicated. Values in square brackets indicate no. of patients that differ due to missing data. Hb = hemoglobin; WBC = white blood cells; CI = confidence interval. Rosette frequency was analyzed by the Mann-Whitney U test (Kenya) or the Kruskal-Wallis test (Mali). Other parameters were analyzed by analysis of variance or Student’s t-test.

^†Percentage of infected red blood cells in 1,000 red blood cells counted.

^‡Percentage of infected red blood cells binding ≥ 2 uninfected red blood cells in 200 infected red blood cells counted.

^§Mean (SD) values for additional biochemical tests in severe case are pH 7.26 (0.15), n = 23, bicarbonate 13.97 mmol/L (5.85), n = 23, and lactate 6.91 mg/dL (4.35), n = 23. These tests were not available for uncomplicated cases in Kenya or any samples from Mali.