Table II.
Comparison of three PAH variations among African-Americans
| Case Genotype | Control Genotype | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Nuc | 11 | 12 | 22 | 11 | 12 | 22 | Case Freq |
Control Freq |
Y | p-value |
| K274E | 1 = A 2 = G |
523 | 16 | 0 | 369 | 17 | 0 | 0.985 | 0.978 | 1.35 | 0.246 |
| L321L | 1 = C 2 = T |
483 | 52 | 2 | 326 | 57 | 0 | 0.948 | 0.926 | 3.96 | 0.047 |
| N426N | 1 = C 2 = T |
9 | 138 | 386 | 9 | 83 | 287 | 0.146 | 0.133 | 0.63 | 0.428 |
Case-control analyses of 3 exonic PAH variations (referred to in text as ‘rare variants’) among an African-American case-control sample. Nuc = nucleotide. Freq = allele frequency provided for allele 1. Y, p-value: results of trends test from distribution of genotypes.
*
Fisher’s exact test p-value: K274E, p = 0.207, L321L, p = 0.017.