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. Author manuscript; available in PMC: 2010 Jul 30.
Published in final edited form as: Neuron. 2009 Jul 30;63(2):178–188. doi: 10.1016/j.neuron.2009.07.003

Figure 1.

Figure 1

A. Distribution volume ratio (DVR) maps of 11-C PiB activity in representative subjects from the study. Color scale from blue = low (1.0 DVR) to red = very high (3.0 DVR) levels of PiB retention. Shown on the Left is a 76 year old cognitively normal woman (CDR rating of 0) showing no evidence of specific cortical PiB retention (PiB-); Middle is a 75 year old woman, also cognitively normal (CDR 0) demonstrating elevated PiB retention in several regions of heteromodal cortices, especially precuneus/posterior cingulate (PPC) regions; Right is a 77 year old man, diagnosed with mild AD (CDR 1) demonstrating high levels of PiB retention in multiple cortical areas. B. Scatterplot of the anatomically defined PPC DVR values for the CDR 0 (n=22) and CDR 0.5 (n=13) groups compared to a group of AD patients (all CDR 1.0) imaged in a previous study (Johnson et al., 2007). Dots shown in red represent the CDR 0 and CDR 0.5 subjects who were classified as PiB+, based on a cut-off of PPC DVR >1.6, the lower end of PPC DVR values in the AD patients.