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A. Whole brain exploratory analysis of PPC PiB DVR and fMRI activity across all 35 older subjects demonstrating significant positive correlations in multiple regions in the default network, as well as regions which activated during memory encoding. B. Regression of PiB and fMRI response from hippocampal ROI (circled region in 6A; R=.44; p<0.01) C. ANOVA of PiB and CDR groups demonstrated a significant effect on PiB on hippocampal activity only among the CDR 0.5 group (p<0.05).
