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. Author manuscript; available in PMC: 2010 Jun 20.
Published in final edited form as: J Comp Neurol. 2009 Jun 20;514(6):567–582. doi: 10.1002/cne.22052

Figure 3.

Figure 3

ICV infusion of GCV for 28 days dramatically reduces both cell proliferation and the number of immature neurons in the SVZ-olfactory bulb pathway of nestin-tk+ (tk+) mice. A–C: While the SVZ of both vehicle-treated tk+ (A) and GCV treated wild-type (wt; B) mice contains numerous mitotically active cells labeled by MCM2, little labeling is observed in the SVZ of tk+ mice treated with 28 days of GCV (C). D–F: Immature neurons labeled by DCx are absent from the SVZ of tk+ mice treated with GCV (F), but are not depleted in vehicle (D) or GCV (E) treated controls. G–I: The ultimate destination of neurons generated in the SVZ, the olfactory bulb, also demonstrates reduced DCx labeling of immature neurons in tk+ mice treated with GCV (I) relative to controls (G,H). LV, lateral ventricle; STM, striatum; CC, corpus callosum; SEZ, olfactory subependymal zone; GCL, granule cell layer; GLL, glomerular layer. Scale bars = 100 μm.