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. Author manuscript; available in PMC: 2010 Jun 20.
Published in final edited form as: J Comp Neurol. 2009 Jun 20;514(6):567–582. doi: 10.1002/cne.22052

Figure 8.

Figure 8

Imipramine produced antidepressant-like effects in the tail suspension test in non-implanted FVB mice (A) and in GCV-treated wild-type (wt) and nestin-tk+ (tk+) mice (B). In non-implanted FVB mice (A), 28d administration of imipramine (i.p.) produced dose-dependent decreases in immobility with significant reductions observed at 10 and 30 mg/kg. Similarly, chronic administration of 10 and 30 mg/kg imipramine significantly decreased immobility in the tail suspension test in GCV-treated wild-type and nestin-tk+ mice (B); however, there was no significant difference between wild-type and nestin-tk+ mice. * p<0.05 as compared with vehicle (0 mg/kg imipramine) and ***p<0.001 as compared with vehicle (0 mg/kg imipramine) as determined by one- or two-way ANOVA with Dunnett’s post hoc tests. C-D: Doublecortin immunostaining of representative sections from GCV-treated wild-type (C) and nestin-tk+ mice (D) used in the depression studies. The transgenic mouse shows complete loss of immature neurons (D) while the wild-type littermate maintains robust labeling (E). Scale bar = 100 μm.