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a Reagents: (a) Ethylcyanoacetate, Et3N, Sulfur, DMF, 55 °C, 3h; (b) carbamimidic chloride hydrochloride, DMSO2, 120 °C, 1 h; (c) (1) Hg(AcO)2, AcOH, 100 °C, 3 h; (2) I2, CH2Cl2, rt, 5 h; (d) thiols, Pd2(dba)3, Xantphos, i-Pr2NEt, DMF, microwave 190 °C, 30 min; (e) 1 N NaOH, MeOH; (f) Lglutamate hydrochloride, 2-chloro-4,6-dimethoxy-1,3,5-triazine, N-methylmorpholine, DMF, rt, 5h; (g) 1 N NaOH, EtOH.
