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. Author manuscript; available in PMC: 2010 Aug 13.
Published in final edited form as: J Med Chem. 2009 Aug 13;52(15):4892–4902. doi: 10.1021/jm900490a

Table 2.

Cytotoxic Evaluation (GI50, M) of Compounds 1 and 2 against Selected Tumor Cell Lines.

cell line GI50 of 1 (M) GI50 of 2 (M)
Leukemia
CCRF-CEM 9.45 × 10−5 8.53 × 10−7
HL-60 (TB) 4.97 × 10−7
MOLT-4 >1.00 × 10−4 4.78× 10−6
Non-Small Cell Lung Cancer
NCI-H460 4.12 × 10−5 9.59 × 10−7
NCI-H525 >1.00 × 10−4 7.80 × 10−6
NCI-H23 >1.00 × 10−4 9.40 × 10−6
Colon Cancer
HCC-2998 >1.00 × 10−4 9.65 × 10−7
HCT-116 >1.00 × 10−4 2.84 × 10−7
Melanoma
LOX IMVI 6.56 × 10−5 9.09 × 10−8
M14 >1.00 × 10−4 4.32× 10−6
Ovarian Cancer
OVCAR-8 >1.00 × 10−4 5.79 × 10−7
Renal Cancer
786-0 >1.00 × 10−4 8.17 × 10−7
SN12C >1.00 × 10−4 3.31 × 10−6